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Response to methylphenidate by adult and pediatric patients with attention-deficit/hyperactivity disorder: The spanish multicenter dihana study

Publicated to:Neuropsychiatric Disease And Treatment. 9 211-218 - 2013-02-07 9(), DOI: 10.2147/NDT.S35836

Authors: Valdizán-Usón JR; Cánovas-Martínez A; de Lucas-Taracena MT; Díaz-Atienza F; Eddy-Ives LS; Fernández-Jaén A; Fernández-Pérez M; García-Giral M; García-Magán P; Garraus-Oneca M; Idiazábal-Alecha MA; López-Benito M; Lorenzo-Sanz G; Martínez-Antón J; Martínez-Granero MA; Montañés-Rada F; Mulas-Delgado F; Ochando-Perales G; Ortega-García E; Pelaz-Antolín A; Ramos-Quiroga JA; Ruiz-Sanz FC; Vaquerizo-Madrid J; Yusta-Izquierdo A

Affiliations

Abstract

Background: The purpose of this multicenter Spanish study was to evaluate the response to immediate-release methylphenidate by children and adults diagnosed with attention-deficit/hyperactivity disorder (ADHD), as well as to obtain information on current therapy patterns and safety characteristics. Methods: This multicenter, observational, retrospective, noninterventional study included 730 patients aged 4-65 years with a diagnosis of ADHD. Information was obtained based on a review of medical records for the years 2002-2006 in sequential order. Results: The ADHD predominantly inattentive subtype affected 29.7% of patients, ADHD predominantly hyperactive-impulsive was found in 5.2%, and the combined subtype in 65.1%. Overall, a significant lower Clinical Global Impression (CGI) score and mean number of DSM-IV TR (Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision) symptoms by subtype were found after one year of treatment with immediate-release methylphenidate; CGI decreased from 4.51 to 1.69, symptoms of inattention from 7.90 to 4.34, symptoms of hyperactivity from 6.73 to 3.39, and combined subtype symptoms from 14.62 to 7.7. Satisfaction with immediate-release methylphenidate after one year was evaluated as "very satisfied" or "satisfied" by 86.90% of the sample; 25.75% of all patients reported at least one adverse effect. At the end of the study, 41.47% of all the patients treated with immediate-release methylphenidate were still receiving it, with a mean time of 3.80 years on therapy. Conclusion: Good efficacy and safety results were found for immediate-release methylphenidate in patients with ADHD. © 2013 Valdiza ́n-Usón et al, publisher and licensee Dove Medical Press Ltd.

Keywords

AdhdAttention deficit hyperactivity disorderMethylphenidatePharmacologic treatmentSatisfaction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neuropsychiatric Disease And Treatment due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position 68/136, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Psychiatry. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Psychiatry and Mental Health.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.18, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-06, the following number of citations:

  • Scopus: 8
  • OpenCitations: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 51.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 51 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.25.
  • The number of mentions on the social network Facebook: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Granada.