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LS is supported by the Spanish Agencia Estatal de Investigacion, AEI, (grant number PID2021-126426OB-I00) and the "Beatriz Galindo senior" Program from the Spanish Ministry of Universities. RPR is supported by the University of Valladolid.

Analysis of institutional authors

Horrillo, DanielAuthor

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Review

Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease

Publicated to:International Journal Of Molecular Sciences. 25 (22): 12320- - 2024-11-01 25(22), DOI: 10.3390/ijms252212320

Authors: de la Puente-aldea, Juan; Lopez-Llanos, Oscar; Horrillo, Daniel; Marcos-Sanchez, Hortensia; Sanz-Ballesteros, Sandra; Franco, Raquel; Jaisser, Frederic; Senovilla, Laura; Palacios-Ramirez, Roberto

Affiliations

Hosp Clin Univ, Valladolid 47003, Spain - Author
Inst Gustave Roussy, Metabol & Cell Biol Platforms, F-94805 Villejuif, France - Author
Sorbonne Univ, Inst Univ France, Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc,INSERM,U1138, F-75006 Paris, France - Author
Sorbonne Univ, Team Diabet Metab Dis & Comorbid, INSERM, U1166, F-75013 Paris, France - Author
Univ Lorraine, Ctr Invest Clin Plurithemat 1433, INSERM, UMR 1116,CHRU Nancy,French Clin Res Infrastruct Ne, F-54500 Nancy, France - Author
Univ Rey Juan Carlos, Fac Ciencias Salud, Alcorcon 28922, Spain - Author
Univ Valladolid, Unidad Excelencia, Inst Biol & Genet Mol IBGM, CSIC, Valladolid 47003, Spain - Author
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Abstract

The classical function of the mineralocorticoid receptor (MR) is to maintain electrolytic homeostasis and control extracellular volume and blood pressure. The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as sleep physiology, playing a role in the non-rapid eye movement (NREM) phase of sleep. Some patients with psychiatric disorders have very poor sleep quality, and a relationship between MR dysregulation and this disorder has been found in them. In addition, the MR is involved in the regulation of the renal peripheral clock. One of the most common comorbidities observed in patients with chronic kidney disease (CKD) is poor sleep quality. Patients with CKD experience sleep disturbances, including reduced sleep duration, sleep fragmentation, and insomnia. To date, no studies have specifically investigated the relationship between MR activation and CKD-associated sleep disturbances. However, in this review, we analyzed the environment that occurs in CKD and proposed two MR-related mechanisms that may be responsible for these sleep disturbances: the circadian clock disruption and the high levels of MR agonist observed in CKD.

Keywords

11-beta-hydroxysteroid dehydrogenaseAldosteroneAnimalsBlood-pressureChronic kidney diseasChronic kidney diseaseCircadian clockCircadian clocksClock protein per1ExpressioGlucocorticoid-receptorsHpa axisHumansHypothalamo-hypophyseal systemMineralocorticoid receptorMolecular clockOf-lifePituitary-adrenal systemReceptors, mineralocorticoidRenal insufficiency, chronicSleep qualitySleep wake disorders

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 68/231, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 15.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France.