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This study was supported by the public institution: Ministerio de Ciencia e Innovacion-MINCINN (SAF2012-40075-C02-01).

Analysis of institutional authors

Paniagua, NAuthorSanchez-Robles, EmAuthorBagues, ACorresponding AuthorGoicoechea, CAuthorGiron, RAuthor

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September 27, 2022
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Behavior and electrophysiology studies of the peripheral neuropathy induced by individual and co-administration of paclitaxel and oxaliplatin in rat

Publicated to:Life Sciences. 277 (119397): 119397- - 2021-07-15 277(119397), DOI: 10.1016/j.lfs.2021.119397

Authors: Paniagua, N; Sanchez-Robles, E M; Bagues, A; Martin-Fontelles, M, I; Goicoechea, C; Giron, R

Affiliations

Univ Rey Juan Carlos, Fac Ciencias Salud, Dept CC Basicas Salud,High Performance Res Grp Ex, Area Farmacol Nutr & Bromatol,Unidad Asociada CSI, Alcorcon, Spain - Author

Abstract

Aims: Antitumor agents, as taxanes and platinum compounds, induce peripheral neuropathies which can hamper their use for cancer treatment. The study of chemotherapy-induced neuropathies in humans is difficult because of ethical reasons, differences among administration protocols and intrinsic characteristics of patients. The aim of the present study is to compare the neuropathic signs induced by individual or combined administration of paclitaxel and oxaliplatin. Main methods: Oxaliplatin and paclitaxel were administered individually and combined to induce peripheral neuropathy in rats, sensory neuropathic signs were assessed in the hind limbs and orofacial area. The in vitro skinsaphenous nerve preparation was used to record the axonal activity of AS sensory neurons. Key findings: Animals treated with the combination developed mechanical allodynia in the paws and muscular hyperalgesia in the orofacial area, which was similar to that in animals treated with monotherapy, the latter also developed cold allodynia in the paws. AS-fibers of the rats treated with the combination were hyperexcited and presented hypersensitivity to pressure stimulation of the innervated skin, also similar to that recorded in the fibers of the animals treated with monotherapy. Significance: Our work objectively demonstrates that the combination of a platinum compound with a taxane does not worsen the development of sensorial neuropathies in rats, which is an interesting data to take into account when the combination of antitumor drugs is necessary. Co-administration of antitumor drugs is more effective in cancer treatment without increasing the risk of the disabling neuropathic side effects.

Keywords

A?-fibersAcetone testAnimalAnimal behaviorAnimal experimentAnimal modelAnimal tissueAnimalsAntineoplastic agentAntineoplastic combined chemotherapy protocolsArticleAs-fibersAδ-fibersBehavior, animalBody weightCannabinoid agonistChemotherapyChemotherapy peripheral neuropathyChemotherapy-induced peripheral neuropathyControlled studyDrug effectElectrophysiologyExpressionIn vitro studyMaleMalignant neoplasmMechanical allodyniaModelMonotherapyNervous system electrophysiologyNonhumanOrofacial painOxaliplatinPaclitaxelPathologyPeripheral nervous system diseasesPeripheral neuropathyProceduresPsychologyRatRatsRats, wistarReceptorsSensory neuronsTetrodotoxinVincristineVon frey testWistar rat

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Life Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 36/279, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.53, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-06, the following number of citations:

  • WoS: 4
  • Scopus: 6
  • Europe PMC: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-06:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Paniagua Lora, Nancy Antonieta) and Last Author (Girón Moreno, María del Rocío).

the author responsible for correspondence tasks has been Bagües Arias, Ana.