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Grant support

This work was carried out in the frame of the Junta de Andalucia FQM-195. Authors want to thank Centro de Instrumentation Cien-tifica of the University of Granada and their technicians for sample measuring and assistance. A warm memory to Prof. J.M. Salas, without whose work during more than three decades in the fields of bioinorganic chemistry and neglected diseases this research would not have been possible. Dr. J.M. Mendez-Arriaga also wants to thank Dr. I. Oyarzabal her significant help and fruitful discus-sions during these years.

Analysis of institutional authors

Mendez-Arriaga, JmCorresponding Author
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Article

In vitro leishmanicidal activity of copper (II) 5,7-dimethyl-1,2,4-triazolo [1,5-a]pyrimidine complex and analogous transition metal series

Publicated to:Polyhedron. 176 (114272): 114272- - 2020-01-15 176(114272), DOI: 10.1016/j.poly.2019.114272

Authors: Méndez-Arriaga, JM; Rodríguez-Diéguez, A; Sánchez-Moreno, M

Affiliations

Univ Granada, Dept Parasitol, Avda Fuentenueva, E-18071 Granada, Spain - Author
Univ Granada, Dept Quim Inorgan, Avda Fuentenueva, E-18071 Granada, Spain - Author
Univ Rey Juan Carlos, Dept Biol & Geol, ESCET, COMET NANO Grp,Fis & Quim Inorgan, C Tulipan S-N, E-28933 Madrid, Spain - Author

Abstract

A series of triazolopyrimidine transition metals complexes have been synthesized by the reaction between the derivative 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) with M(NO3)(2)center dot XH2O (M Cu(II), Co(II), Ni(II) and Zn(II)). These four compounds have been characterized by spectroscopic and thermal analysis and the crystal structure of the Cu(II) one has been solved by X-ray diffraction methods. The in vitro antiparasitic activity of these complexes against four leishmania spp. strands and their toxicity against macrophage host cells have also been studied, in order to elucidate the influence of different metal centres in the leishmanicidal effect to fight neglected tropical diseases. (C) 2019 Elsevier Ltd. All rights reserved.

Keywords
AgentsAntiparasitic activityCoordination chemistryDerivativesDesignDnaInsightsLeishmaniaLigandPyrimidineSilver(i) complexesStructure descriptionTriazolopyrimidine

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Polyhedron due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 8/25, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Crystallography. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Materials Chemistry.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.07. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 2.64 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-12, the following number of citations:

  • WoS: 16
  • Scopus: 19
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 15.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Méndez Arriaga, José Manuel) .

the author responsible for correspondence tasks has been Méndez Arriaga, José Manuel.