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A.M.L.-P. is supported by the predoctoral industry national grant of the Ministerio de Ciencia, Innovacion y Universidades inside the National Subprogram of Education (DIN2018-010129). The author S.V. was supported by a grant from the regional department of economy and infrastructure of the Government of Extremadura and the European Social Fund (PD16008).

Analysis of institutional authors

Lavin-Perez, AmAuthorCollado-Mateo, DAuthor

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Review

The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A Systematic Review

Publicated to:Medicina-Lithuania. 57 (2): 1-16 - 2021-02-01 57(2), DOI: 10.3390/medicina57020159

Authors: Lavin-Perez, Ana Myriam; Collado-Mateo, Daniel; Villafaina, Santos; Calle-Guisado, Violeta

Affiliations

Ingesport, GO FitLAB, Madrid 28003, Spain - Author
Rey Juan Carlos Univ, Ctr Sport Studies, Madrid 28943, Spain - Author
Univ Extremadura, Fac Sport Sci, Phys Act & Qual Life Res Grp AFYCAV, Caceres 10004, Spain - Author
Univ Zaragoza, Fac Human Sci & Educ, Dept Specif Didact, Expt Sci Area, Zaragoza 50009, Spain - Author

Abstract

Background and Objectives: One of the most relevant consequences of diabetes mellitus is the temporal or complete infertility which can happen in young individuals. Therefore, the current systematic review aimed to investigate the effects of exercise to reduce the impact of Type 2 Diabetes Mellitus (T2DM) in seminal quality and related parameters. Materials and Methods: A systematic search was conducted in Pubmed and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA). The inclusion criteria were: (1) the study included at least one experimental and one comparison group, (2) the sample of the study was comprised of humans or animals with diabetes mellitus, (3) an intervention based on physical exercise was conducted, and (4) the study reported variables related to the seminal quality. Results: A total of 115 articles were identified. However, only six accomplished the inclusion and exclusion criteria. This systematic review includes a sample size of 260 participants (180 rats and 80 humans). Intervention ranged from 6 to 14 weeks, with 3-6 days per week. All interventions performed endurance training (50-70% VO(2)max or maximum heart rate). Physical exercise increased sperm count, motility, and morphology, as well as improved testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) levels. Moreover, physical exercise intervention reduced the percentages of sperms with negative Tubular Differentiation Index (TDI) and Spermiogenesis Index (SPI), DNA fragmentation, and also ameliorated the diabetes-induced apoptosis and improved sperm apoptosis index. Conclusions: Physical exercise could ameliorate diabetic pathological effects on sperm quality and related parameters that cause infertility or subfertility conditions. However, further homogeneous studies are needed to confirm these findings.

Keywords

AnimalAnimalsAxisDiabetesDiabetes mellitus, type 2Dna fragmentationFertilityHumanLuteinizing hormoneMaleMellitusNon insulin dependent diabetes mellitusPhysical exerciseRatRatsRiskSemenSperm qualitySpermatozoaSpermatozoonTestosteroneType-2

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Medicina-Lithuania due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Medicine, General & Internal.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.39, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-15, the following number of citations:

  • WoS: 4
  • Scopus: 9
  • Europe PMC: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-15:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 40 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Lavín Pérez, Ana Myriam) .