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Supported by the grant From the theory to the practice of the Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU). The English Language edition was supported by Cosmos Specialized Services (Madrid, Spain).; F. Bermejo has served as a speaker and consultant from MSD and Abbvie. A. Algaba reports grants from MSD. J. P. Gisbert has served as a speaker, a consultant, and advisory member for or has received research funding from MSD, Abbvie, Hospira, Kern Pharma, Takeda, Janssen, Pfizer, Ferring, Faes Farma, Shire Pharmaceuticals, Dr. Falk Pharma, Chiesi, Casen Fleet, Gebro Pharma, Otsuka Pharmaceutical, and Vifor Pharma. The remaining authors have no conflict of interest to disclose.

Analysis of institutional authors

Paez, AAuthorBermejo, FAuthor

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September 27, 2022
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Evaluation of the Quality of Semen and Sexual Function in Men with Inflammatory Bowel Disease

Publicated to:Inflammatory Bowel Diseases. 23 (7): 1144-1153 - 2017-07-01 23(7), DOI: 10.1097/MIB.0000000000001081

Authors: Valer, P; Algaba, A; Santos, D; Fuentes, ME; Nieto, E; Gisbert, JP; López, P; Quintanilla, E; García-Alonso, FJ; Guerra, I; Páez, A; Bermejo, F

Affiliations

Hosp Clin San Carlos, Dept Urol, Madrid, Spain - Author
Hosp Univ Fdn Alcorcon, Dept Gastroenterol, Alcorcon, Spain - Author
Hosp Univ Fuenlabrada, Dept Biochem, Fuenlabrada, Spain - Author
Hosp Univ Fuenlabrada, Dept Gastroenterol, Camino Molino 2, Fuenlabrada 28942, Spain - Author
Hosp Univ Fuenlabrada, Dept Urol, Fuenlabrada, Spain - Author
Hosp Univ Princesa, Dept Gastroenterol, Madrid, Spain - Author
Hosp Univ Severo Ochoa, Dept Gastroenterol, Leganes, Spain - Author
Univ Camilo Jose Cela, Unidad Gest Serv Med Prevent, Hosp Clin San Carlos, Unidad Metodol Invest & Epidemiol Clin,Inst Inves, Madrid, Spain - Author
Univ Rey Juan Carlos, Dept Commun Sci, Madrid, Spain - Author
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Abstract

Background: Data on fertility rates and medication safety in men with inflammatory bowel disease (IBD) are limited. The aim of this study was to evaluate whether there is a seminal alteration in patients with IBD and, if so, to evaluate the mechanisms that may play a role according to what has been described in the literature. Its secondary aim was to evaluate the impact on male sexual function of IBD. Methods: Multicenter, cross-sectional, case series study comparing men with IBD and control subjects. Semen analysis was performed according to the recommendations of World Health Organization. The impact on male sexual function was evaluated with the International Index of Erectile Function questionnaire. Results: On multivariate analysis, patients with Crohn's disease had lower sperm concentrations compared with those with ulcerative colitis (median [interquartile range], 34.5 [19.2-48] versus 70 [34.5-127.5], P = 0.02) and lower seminal zinc levels (mean +/- SD, 1475 +/- 235 mmol/L versus 2221 +/- 1123 mmol/L, P = 0.04). Patients with Crohn's disease on anti-tumor necrosis factor treatment had better progressive motility (mean +/- SD, 56.7 +/- 17.7 versus 35.1 +/- 22.1, P = 0.01) and sperm morphology (14.4 +/- 7.1 versus 7.6 +/- 4.9, P = 0.04) than those who were not on anti-tumor necrosis factor. Regarding sexual function, no significant differences were found across patients with IBD and control subjects. Conclusions: Men with Crohn's disease showed a trend toward poorer semen quality than those with ulcerative colitis. Treatment with anti-tumor necrosis factor drugs does not seem to be associated with poor sperm quality. In patients in clinical remission, male sexual function is not affected by IBD.

Keywords

AdalimumabAdultAgeAlbuminAnti-tnf treatmentArticleCase control studyCase-control studiesChemistryClinical articleClinical trialControlled studyCrohn diseaseCrohns-diseaseCross-sectional studiesCross-sectional studyErectile functionEvaluation studyFollitropinFollow upFollow-up studiesHumanHuman spermatozoaHumansIll healthImmunosuppressive treatmentIncidenceInflammatory bowel diseaseInflammatory bowel diseasesInfliximabInternational indexInternational index of erectile functionLuteinizing hormoneMaleMale genital tract parametersMulticenter studyNecrosis-factor-alphaOrgasmPathophysiologyPhysiologyPriority journalPrognosisProlactinQuality of lifeSemenSemen analysisSemen qualitySexual dysfunctionSexual dysfunction, physiologicalSexual functionSexual satisfactionSexualitySmokingSpainSpermSperm characteristicsSperm qualitySperm vitalitySpermatozoon countSpermatozoon motilityUlcerative colitisUlcerative-colitisYoung menZincZinc-deficiency

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Inflammatory Bowel Diseases due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 17/80, thus managing to position itself as a Q1 (Primer Cuartil), in the category Gastroenterology & Hepatology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 8.6, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-12, the following number of citations:

  • WoS: 24
  • Scopus: 26

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 60.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 60 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.25.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Bermejo San José, Fernando).