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Review

Hexavalent vaccines: A fact in vaccination future [Las vacunas hexavalentes: Una realidad en el futuro de la vacunación]

Publicated to:Pediatrika. 23 (7): 37-44 - 2003-01-01 23(7), DOI:

Authors: Alcalde Tuñón MR; Murciano M; Moreno O; Saburrido MA; Fernández Clemente ME

Affiliations

Aventis Pasteur MSD, Universidad Rey Juan Carlos, Madrid, Spain - Author
C. S. Parque Coimbra, VII Promo. Diploma Expertos Vacunas, Universidad Rey Juan Carlos, Area 8 de Atencion Primaria, Madrid, Spain - Author
Invest. de Med. Prev. y Salud Pub., Facultad Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain, Departamento de Medicina Preventiva, Universidad Rey Juan Carlos, Avda. Atenas, s/n, E-28922 Alcorcón, Madrid, Spain - Author

Abstract

Hexavalent vaccines combine antigens against six infectious diseases with only one unit of simple administration. This fact implies many advantages: vaccination against polio with IPV, vaccination with aP (acellular Pertussis), reduction of the number of injections, better vaccination coverages, to simplify vaccination programs, posible reduction of vaccination programs price and easier transport and storage. Nevertheless, combined vaccines must also go beyond a series of problems: the combination must be safe, there must not be inmunology interferences, effectiveness, safety and tolerance must be the same or higher than monovalent vaccines, the adjuvants and excipients must not interfere with the antigens and the whole volume to inject must be small. Lots of studies have proved that hexavalent vaccines have gone beyond these problems. A review has been made about the use of hexavalent vaccines (DTaP-IPV-PRT-T-HBs), analysing the suitability of the introduction of this vaccines in the vaccination schedules.

Keywords
Acellular vaccineAdjuvantAntigenBlood clotting disorderConvulsionCost minimization analysisDiphtheriaDiphtheria pertussis poliomyelitis tetanus haemophilus influenzae type b hepatitis b vaccineDiphtheria pertussis tetanus vaccineDrug contraindicationDrug costDrug efficacyDrug indicationDrug safetyDrug storageDrug tolerabilityDrug transportExcipientFeverHaemophilus influenzae type b vaccineHealth programHealth promotionHepatitis bHepatitis b vaccineHexavalent vaccineHexavalent vaccinesHumanImmunogenicityInfectionInfluenzaInjectionPentavaxPertussisPertussis vaccinePoliomyelitisPoliomyelitis vaccineReviewShockThrombocytopeniaUnclassified drugVaccinationVaccination coverageVaccination schedulesVaccineVirus meningitis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Pediatrika, Q4 Agency Scopus (SJR), its regional focus and specialization in Pediatrics, Perinatology and Child Health, give it significant recognition in a specific niche of scientific knowledge at an international level.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author () and Last Author ().

the author responsible for correspondence tasks has been .