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Grant support

This work was funded by Ministerio de Economia, Industria y Competitividad (Project MTM2016-80539-C2-1-R). E. Hernandez-Balaguera expresses his gratitude to the Universidad de Castilla-La Mancha (01110/541A) for the Pre-PhD contract granted to him. We also thank Dr. Felix Viana de la Iglesia for the use of his facilities at the Laboratory of Sensory Transduction and Nociception (Instituto de Neurociencias de Alicante), and Dr. Jan-Albert Manenschijn for his help with DRG cell cultures.

Analysis of institutional authors

Hernandez-Balaguera, EAuthor

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Article

Identification of Capacitance Distribution in Neuronal Membranes from a Fractional-Order Electrical Circuit and Whole-Cell Patch-Clamped Cells

Publicated to:Journal Of The Electrochemical Society. 165 (12): G3104-G3111 - 2018-08-08 165(12), DOI: 10.1149/2.0161812jes

Authors: Hernandez-Balaguera, E; Vara, H; Polo, J L

Affiliations

Hosp Nacl Paraplejicos, SESCAM, Toledo 45071, Spain - Author
Univ Castilla La Mancha, Escuela Ingn Ind Toledo, Toledo 45071, Spain - Author

Abstract

Passive electrical membrane properties are key determinants of signaling processes in brain cells, influencing input-output responses as well as action potential firing. We propose a novel interpretation of patch-clamp recordings that brings out the fractional dynamic of the electrical properties of cell membranes and provides a better knowledge of their microscopic behavior. The passive electrical properties of the cell membrane were modeled using an electrical equivalent circuit (EEC) consisting of a constant phase element (CPE) in parallel with a resistor. The Mittag-Leffler function was used to describe the non-exponential behavior of the voltage transients that are attributable to the processes of charging and discharging the membrane capacitance. The procedure proposed, based on circuit theory and fractional calculus, was used to study the voltage transients obtained in response to low-amplitude hyperpolarizing current pulses applied to cultured mice dorsal root ganglion (DRG) neurons under whole-cell current-clamp configuration. To further validate the method, we also analyzed the voltage transients obtained from hippocampal pyramidal neurons and glial cells recorded in mice brain slices in vitro using the short-time behavior of the resulting membrane voltages. (C) The Author(s) 2018. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License.

Keywords

Electrotonic lengthGlial-cellsMicrodomainsRatTime constant

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of The Electrochemical Society due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 4/20, thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Science, Coatings & Films.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.63, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-10, the following number of citations:

  • WoS: 15
  • Scopus: 16
  • OpenCitations: 16

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-10:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 18 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Hernández Balaguera, Enrique) .