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Analysis of institutional authors

Martínez-García, GonzaloAuthor

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October 18, 2022
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Article

An Electrochemical Enzyme Biosensor for 3-Hydroxybutyrate Detection Using Screen-Printed Electrodes Modified by Reduced Graphene Oxide and Thionine

Publicated to: Biosensors. 7 (4): 50- - 2017-12-01 7(4), DOI: 10.3390/bios7040050

Authors:

Martinez-Garcia, Gonzalo; Perez-Julian, Elena; Agui, Lourdes; Cabre, Naomi; Joven, Jorge; Yanez-Sedeno, Paloma; Manuel Pingarron, Jose
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Affiliations

Ant Hosp Univ St Joan, CRB, URB, C St Joan S-N, Reus 43201, Spain - Author
Univ Complutense Madrid, Fac CC Quim, Dept Quim Analit, E-28040 Madrid, Spain - Author

Abstract

A biosensor for 3-hydroxybutyrate (3-HB) involving immobilization of the enzyme 3-hydroxybutyrate dehydrogenase onto a screen-printed carbon electrode modified with reduced graphene oxide (GO) and thionine (THI) is reported here. After addition of 3-hydroxybutyrate or the sample in the presence of NAD(+) cofactor, the generated NADH could be detected amperometrically at 0.0 V vs. Ag pseudo reference electrode. Under the optimized experimental conditions, a calibration plot for 3-HB was constructed showing a wide linear range between 0.010 and 0.400 mM 3-HB which covers the clinically relevant levels for diluted serum samples. In addition, a limit of detection of 1.0 mu M, much lower than that reported using other biosensors, was achieved. The analytical usefulness of the developed biosensor was demonstrated via application to spiked serum samples.
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Keywords

3-hydroxybutyrate3-hydroxybutyric acidAmperometric biosensorBeta-hydroxybutyrateBiosensing techniquesBloodDiabetic ketoacidosisElectrochemical biosensorElectrodesFabricationGrapheneGraphiteKetone 3-beta-hydroxybutyrateManagementPhenothiazinesReductionSensorsThionine

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biosensors due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.48, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-01-22, the following number of citations:

  • WoS: 31
  • Scopus: 33
  • Europe PMC: 7
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 91.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 91 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Martínez García, Gonzalo) .

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Awards linked to the item

The financial support of the CTQ2015-70023-R and CTQ2015-64402-C2-1-R (Spanish Ministerio de Economia y Competitividad Research Projects) and S2013/MT3029 (NANOAVANSENS Program from the Comunidad de Madrid) are gratefully acknowledged.
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