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This work was supported by grants SAF2015-66986-R (Spanish Ministry of Economy and Competitiveness), Beca I-UnoEntreCienMil (Uno Entre Cien Mil Foundation), RD16/0011/0003 (Institute of Health Carlos III, Spain) and B2017/BMD-3692 AvanCell-CM (Community of Madrid). A.F-R. was supported by Grant PR41/17-20974 (Santander-Universidad Complutense de Madrid). L.M.F-S. is supported by a pre -doctoral fellowship (CT45/15-CT46/15) from the Complutense University of Madrid.

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Martínez Fernandez De Sevilla, LidiaAuthor

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Article

Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4

Publicated to:Cells. 8 (7): E722- - 2019-07-01 8(7), DOI: 10.3390/cells8070722

Authors: Valencia, Jaris; Fernandez-Sevilla, Lidia M.; Fraile-Ramos, Alberto; Sacedon, Rosa; Jimenez, Eva; Vicente, Angeles; Varas, Alberto;

Affiliations

Univ Complutense Madrid, Fac Med, Dept Cell Biol, Madrid 28040, Spain - Author

Abstract

Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progression. In the present study, we analyse whether acute lymphoblastic leukaemia (ALL) cells can affect the differentiation of dendritic cells and macrophages and the involvement of BMP pathway in the process. We show that ALL cells produce BMP4 and that conditioned media from ALL cells promote the generation of dendritic cells with immunosuppressive features and skew Ml-like macrophage polarization towards a less pro-inflammatory phenotype. Likewise, BMP4 overexpression in ALL cells potentiates their ability to induce immunosuppressive dendritic cells and favours the generation of M2-like macrophages with pro-tumoral features. These results suggest that BMP4 is in part responsible for the alterations in dendritic cell and macrophage differentiation produced by ALL cells.

Keywords

Acute lymphoblastic leukaemiaBmp4Bone morphogenetic protein 4Bone-marrowCell differentiationCell line, tumorChemotherapyChildrenDendritic cellsHumansMacrophage activationMacrophagesMicroenvironmentPathwayPolarizationPrecursor cell lymphoblastic leukemia-lymphomaStateTumor microenvironmentTumour immune microenvironment

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cells due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 70/195, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Cell Biology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 6.95, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-23, the following number of citations:

  • WoS: 27
  • Scopus: 35
  • Europe PMC: 26
  • OpenCitations: 32

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 34.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 34 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.