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J Egea thanks to IS Carlos III, Programa Miguel Servet (CP14/00008) and grant from Fondo de Investigaciones Sanitarias (FIS) (ISCIII/FEDER) (PI16/00802). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Analysis of institutional authors

De Los Ríos, CristóbalAuthor

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January 23, 2023
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Review
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Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

Publicated to:Future Medicinal Chemistry. 9 (8): 765-780 - 2017-05-01 9(8), DOI: 10.4155/fmc-2017-0014

Authors: Ramos, Eva; Egea, Javier; de los Rios, Cristobal; Marco-Contelles, Jose; Romero, Alejandro

Affiliations

CSIC, Inst Gen Organ Chem, Lab Med Chem, Juan de la Cierva 3, E-28006 Madrid, Spain - Author
Hosp Univ Princesa, Serv Farmacol Clin, Inst Invest Sanitaria, Madrid 28006, Spain - Author
Univ Autonoma Madrid, Fac Med, Inst I D Medicamento Teofilo Hernando ITH, Madrid, Spain - Author
Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain - Author

Abstract

Melatonin is an indoleamine produced mainly in the pineal gland. The natural decline of melatonin levels with aging strongly contributes to the development of neurodegenerative disorders. Pleiotropic actions displayed by melatonin prevent several processes involved in neurodegeneration such as neuroinflammation, oxidative stress, excitotoxicity and/or apoptosis. This review focuses on a number of melatonin hybrids resulting from the juxtaposition of tacrine, berberine, tamoxifen, curcumin, N, N-dibenzyl(N-methyl) amine, among others, with potential therapeutic effects for the treatment of neurodegenerative diseases.

Keywords

Alzheimer's diseaseAlzheimers-disease therapyAntioxidant therapyBeta-amyloid aggregationHybrid compoundsIn-vitroMelatoninMonoamine-oxidase bMouse modelMtdlsMultifunctional agentsMultitarget-directed ligandsNeurodegenerationNeuroprotective propertiesNicotinic acetylcholine-receptorOxidative damageTarget-directed ligands

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Future Medicinal Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 9/59, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.49, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-26, the following number of citations:

  • WoS: 22
  • Scopus: 20

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-26:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 37.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 38 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).