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Perez Del Pulgar, HelenaAuthor

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January 23, 2023
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One-Step Synthesis of Furan Rings from alpha-Isopropylidene Ketones Mediated by Iodine/DMSO: An Approach to Potent Bioactive Terpenes

Publicated to: Journal Of Organic Chemistry. 84 (11): 6886-6894 - 2019-06-07 84(11), DOI: 10.1021/acs.joc.9b00704

Authors:

Salihila, Jonida; Silva, Lucia; Perez del Pulgar, Helena; Quilez Molina, Ana; Gonzalez-Coloma, Azucena; Sonia Olmeda, A; Quilez del Moral, Jose F; Barrero, Alejandro F
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Affiliations

CSIC, Inst Agr Sci, Madrid 28006, Spain - Author
Univ Beira Interior, Dept Chem, FibEnTech Mat Fibrosos & Technol Ambientais, P-6200 Covilha, Portugal - Author
Univ Complutense Madrid, Fac Vet Med, Dept Anim Hlth, Madrid 28040, Spain - Author
Univ Granada, Inst Biotechnol, Dept Organ Chem, E-18071 Granada, Spain - Author
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Abstract

The system I-2/dimethyl sulfoxide mediates the one-step transformation of alpha-isopropylidene ketones into furan rings following a biomimetic approach. This methodology has been used for the synthesis of terpene furans such as mintfurane, curzerene, atractylon, and isoatractylon, all of them possessing interesting biological activities. The synthesis of linderazulene directly from 4,5-epoxygermacrone via a cascade reaction shows the potential of this protocol. Additionally, this compound proved to show significant ixodicidal activity.
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Keywords

AlkenesChemistryConstituentsDimerizationDimethyl sulfoxideEssential oilFuranFuransIn-vitroIodineKetonesLactonesMenthofuranMetabolitesMolecular structurePigmentPropyleneSesquiterpenesTerpenes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Organic Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 9/57, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Organic.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • WoS: 9
  • Scopus: 10
  • Europe PMC: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 22 (PlumX).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Granada; Portugal.

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Awards linked to the item

Financial support for this work was provided by the Junta de Andalucia (P08-FQM-3596) and Ministerio de Economia y Competitividad (CTQ-2015-64049-C3-3-R).
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