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This work was partly supported by Instituto de Investigacion e Innovacion Biomedica de Cadiz (LI19/21IN-CO09), by the Spanish Ministry of Science and Innovation (Ministerio de Ciencia e Innovacion) (MCIN/AEI/ 10.13039/501100011033), grants PID2019-110063RA-I00 and PID2020-120034RA-I00, and by Supreme Council for Sports (CSD) of spanish ministry through the recovery Plan, transformation and Resilience (NextGeneration EU) (Ref: EXP_74977). J.C.-P. is supported by a predoctoral grant from the Spanish Ministry of Education (Ministerio de Educacion) (grant number FPU19/02326). D.V.-D. is supported by the Margarita Salas Postdoctoral Program from European Union Next Generation EU and University of Cadiz.

Analysis of institutional authors

Gomez-Gallego, FelixAuthor

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June 26, 2023
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Impact of the FTO Gene Variation on Appetite and Fat Oxidation in Young Adults

Publicated to:Nutrients. 15 (9): 2037- - 2023-04-23 15(9), DOI: 10.3390/nu15092037

Authors: Ponce-Gonzalez, Jesus G; Martinez-Avila, Angel; Velazquez-Diaz, Daniel; Perez-Bey, Alejandro; Gomez-Gallego, Felix; Marin-Galindo, Alberto; Corral-Perez, Juan; Casals, Cristina

Affiliations

AdventHlth Res Inst, Neurosci Inst, Orlando, FL 32804 USA - Author
Univ Cadiz, Fac Educ Sci, Dept Phys Educ, GALENO Res Grp, Cadiz 11519, Spain - Author
Univ Cadiz, Fac Nursing Salus Infirmorum, Cadiz 11001, Spain - Author
Univ Cadiz, Inst Invest & Innovac Biomed Cadiz INiBICA, Dept Phys Educ, ExPhy Res Grp, Cadiz 11519, Spain - Author
Univ Rey Juan Carlos, Fac Hlth Sci, Alcorcon 28922, Spain - Author
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Abstract

The FTO rs9939609 gene, which presents three polymorphisms (AA, AT, and TT), has been associated with the development of obesity through an increased fat accumulation; however, the associations of the gene with other physiological mechanisms, such as appetite or fat oxidation, are still unclear. Therefore, this study aims to evaluate the influence of the FTO rs9939609 gene on different obesity-related factors in young adults. The FTO rs9939609 polymorphism was genotyped in 73 participants (28 women, 22.27 +/- 3.70 years). Obesity-related factors included dietary assessment, physical activity expenditure, body composition, appetite sensation, resting metabolic rate, maximal fat oxidation during exercise (MFO), and cardiorespiratory fitness. Our results showed that TT allele participants expressed higher values of hunger (p = 0.049) and appetite (p = 0.043) after exercising compared to the AT allele group. Moreover, the TT allele group showed significantly higher values of MFO (p = 0.031) compared to the AT group, regardless of sex and body mass index. Thus, our results suggest that the FTO rs9939609 gene has an influence on appetite, hunger, and fat oxidation during exercise, with TT allele participants showing significantly higher values compared to the AT allele group. These findings may have practical applications for weight loss and exercise programs.

Keywords

AdultAllelesAlpha ketoglutarate dependent dioxygenase ftoAlpha-ketoglutarate-dependent dioxygenase ftoAppetiteArticleBasal metabolic rateBlood samplingBody compositionBody heightBody massBody-mass indexCaloric intakeCarbon dioxideCardiorespiratory fitnessComparative studyControlled studyCross-sectional studyEnergy expenditureExerciseFat massFatty acid oxidationFemaleFto protein, humanGastric inhibitory polypeptideGenetic associationGenetic association studiesGenetic variationGenotypeGhrelinGlucagon like peptide 1GlucoseGlucose blood levelHumanHumansHungerIndirect calorimetryInsulinInsulin blood levelLean body weightLeptinLipid storageLipid utilizationMajor clinical studyMaleMaximal oxygen uptakeMetabolismNutritional assessmentObesityPeptide yyPhysical activityPhysical exercisePhysical-activityResting metabolic rateRs9939609 polymorphismSedentary lifestyleSex differenceSingle nucleotide polymorphismStandingTriacylglycerolTriacylglycerol blood levelVariantWomenYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 18/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 5.97, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-17, the following number of citations:

  • WoS: 5
  • Scopus: 6
  • Europe PMC: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-17:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 40.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 47 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.