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Recio, JavierAuthor

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September 26, 2023
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Microwave-assisted conversion of carbonyl compounds into formylated secondary amines: new contribution to the Leuckart reaction mechanism in N-methylformamide

Publicated to: Tetrahedron Letters. 54 (14): 1835-1838 - 2013-04-03 54(14), DOI: 10.1016/j.tetlet.2013.01.097

Authors: Barba, Fructuoso; Recio, Javier; Batanero, Belen

Affiliations

Univ Alcala de Henares, Dept Organ Chem, Madrid 28871, Spain - Author

Abstract

The reductive amination of several carbonyl compounds (Leuckart reaction) has been performed using N-methylformamide and microwave technology. Under these conditions, a new mechanism is proposed via the initial formation of an imine, followed by reduction to the amine by in situ' generated formic acid, and further formylation of the amine. Using this methodology, the formyl derivatives of several secondary amines were obtained in good to excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.

Keywords

AldehydesAlkylationAminationCyclizationDecompositionDerivativesFormamidesFormic-acidFormylation of aminesLeuckart reactionMicrowave technologyRedox processReductionReductive aminationWallach reaction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Tetrahedron Letters due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position 24/58, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Chemistry, Organic. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Drug Discovery.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-05:

  • WoS: 13
  • Scopus: 13

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on Wikipedia: 1 (Altmetric).

Awards linked to the item

This study was financed by the Spanish Ministry of Science and Education supporting the I3 Program to B. Batanero.