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López-Miranda V.Author

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January 8, 2024
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Pradimicin and Benanomicin Antibiotics: From Antifungal Polyketide Natural Products to Antiviral Agents with a Unique Carbohydrate-Binding Mode of Action

Publicated to: Frontiers In Natural Product Chemistry. 7 31-109 - 2021-01-01 7(), DOI: 10.2174/9781681089164121070004

Authors: Abín R; López-Miranda V; San-Félix A; Quesada E

Affiliations

Área de Farmacología y Nutrición, Departamento de Ciencias Básicas de la Salud, Universidad Rey Juan Carlos (URJC), Alcorcón, Spain - Author
Área de Farmacología y Nutrición, Departamento de Ciencias Básicas de la Salud, Universidad Rey Juan Carlos (URJC), Alcorcón, Spain, Unidad Asociada I+D+i Instituto de Química Médica (IQM-CSIC), Facultad de Ciencias de la Salud (URJC), Madrid, Spain - Author
Instituto de Química Médica (IQM), Department of Biomimetics for Drug Discovery, Agencia Estatal Consejo Superior de Investigaciones Científicas (AE-CSIC), Madrid, Spain - Author
Instituto de Química Médica (IQM), Department of Biomimetics for Drug Discovery, Agencia Estatal Consejo Superior de Investigaciones Científicas (AE-CSIC), Madrid, Spain, Unidad Asociada I+D+i Instituto de Química Médica (IQM-CSIC), Facultad de Ciencias d - Author
Unidad Asociada I+D+i Instituto de Química Médica (IQM-CSIC), Facultad de Ciencias de la Salud (URJC), Madrid, Spain - Author
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Abstract

The family of benanomicin-pradimicin antibiotics (BPAs) is reviewed exhaustively with respect to its structural, functional, mechanistic and synthetic aspects. BPAs can be considered a unique class of compounds from the structural point of view due to the presence of a 5,6-dihydro-benzo[?]naphthacenequinone (DHBNQ) scaffold attached to a glycan moiety. The mechanism of action is ‘lectin-like’ and related to the selective recognition and binding to specific mannoside residues located at the surface of the membrane of fungal and viral pathogens. BPAs are prototype structures of non-peptidic small-size carbohydrate-binding agents (CBAs). © 2021 Bentham Science Publishers.

Keywords

5,6-dihydro-benzo[?]naphthacenequinone (dhbnq)AntibioticsAntifungalAntiviralAromatic polyketidesAtropisomerismBenanomicinBenanomicin-pradimicin antibiotics (bpas)BiosynthesisCarbohydrate-binding agents (cbas)Natural productsPradimicinTotal synthesis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Natural Product Chemistry, Q4 Agency Scopus (SJR), its regional focus and specialization in Analytical Chemistry, give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-05:

  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-05:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 1 (PlumX).