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Viar-Hernández, DCorresponding AuthorRodriguez-Vila, BAuthorMalpica, NAuthorTorrado-Carvajal, AAuthor

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April 25, 2024
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Hybrid Gold

Material decomposition maps based calibration of dual energy CT scanners for proton therapy planning: a phantom study

Publicated to:Physics In Medicine And Biology. 69 (4): 45018- - 2024-02-21 69(4), DOI: 10.1088/1361-6560/ad2015

Authors: Viar-Hernandez, David; Vera-Sanchez, Juan Antonio; Schmidt-Santiago, Lucia; Rodriguez-Vila, Borja; Lorenzo-Villanueva, Isabel; Canals-de-las-Casas, Elisabet; Castro-Novais, Juan; Perez-Moreno, Juan Maria; Cerron-Campoo, Fernando; Malpica, Norberto; Torrado-Carvajal, Angel; Mazal, Alejandro

Affiliations

Hosp Quironsalud, Ctr Protonterapia - Author
Univ Rey Juan Carlos - Author

Abstract

We introduce a new calibration method for dual energy CT (DECT) based on material decomposition (MD) maps, specifically iodine and water MD maps. The aim of this method is to provide the first DECT calibration based on MD maps. The experiments were carried out using a general electric (GE) revolution CT scanner with ultra-fast kV switching and used a density phantom by GAMMEX for calibration and evaluation. The calibration process involves several steps. First, we tested the ability of MD values to reproduce Hounsfield unit (HU) values of single energy CT (SECT) acquisitions and it was found that the errors were below 1%, validating their use for HU reproduction. Next, the different definitions of computed Z values were compared and the robustness of the approach based on the materials' composition was confirmed. Finally, the calibration method was compared with a previous method by Bourque et al, providing a similar level of accuracy and superior performance in terms of precision. Overall, this novel DECT calibration method offers improved accuracy and reliability in determining tissue-specific physical properties. The resulting maps can be valuable for proton therapy treatments, where precise dose calculations and accurate tissue differentiation are crucial for optimal treatment planning and delivery.

Keywords

ArticleCalibrationCalibration methodCancerCell proliferationComputerized tomographyControlled studyCt calibrationCt scannerCt scannersDecompositionDecomposition mapsDiagnostic test accuracy studyDose calculationDual energy computed tomographyDual energy ctDual-energy ctEffective atomic-numberElectron-densityHeadHounsfield unitsIodineMaterial decompositionPhantomPhantom studiesPhantomsPhantoms, imagingProton beam therapyProton beamsProton therapyReliabilityReproducibility of resultsSingleTherapy planningTissueTissue differentiationTomography scanners, x-ray computedTomography, x-ray computedTreatment planningWater

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Physics In Medicine And Biology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 44/212, thus managing to position itself as a Q1 (Primer Cuartil), in the category Radiology, Nuclear Medicine & Medical Imaging.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-02:

  • WoS: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Viar Hernández, David) .

the author responsible for correspondence tasks has been Viar Hernández, David.