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Analysis of institutional authors

Del Coso, JCorresponding AuthorGonzalez-Rodenas, JAuthorFerrandis, JAuthor

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April 25, 2024
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ACTN3 XX Genotype Negatively Affects Running Performance and Increases Muscle Injury Incidence in LaLiga Football Players

Publicated to:Genes. 15 (3): 386- - 2024-03-01 15(3), DOI: 10.3390/genes15030386

Authors: Del Coso, J; Rodas, G; Soler-Aguinaga, A; Campo, RLD; Resta, R; González-Rodenas, J; Ferrandis, J; Moreno-Pérez, V

Affiliations

Catholic Univ Valencia, Fac Phys Educ & Sports Sci, San Vicente Martir - Author
Elche Club Futbol, Strength & Conditioning Dept - Author
Futbol Club Barcelona, Med Dept & Barca Innovat Hub - Author
Liga, Dept Competit - Author
Miguel Hernandez Univ, Fac Med, Translat Res Ctr Physiotherapy, Dept Pathol & Surg - Author
Rey Juan Carlos Univ, Sport Sci Res Ctr - Author
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Abstract

The aim of this study was to investigate the association of the ACTN3 rs1815739 polymorphism with match running performance and injury incidence in top-level professional football players. A total of 315 top-level professional football players from the first division of Spanish football (i.e., LaLiga) participated in this prospective and descriptive study. The ACTN3 rs1815739 genotype was identified for each player using genomic DNA samples. During LaLiga 2021-2022, players' performance was obtained through a validated camera system in all official matches. Additionally, the incidence of non-contact injuries was obtained by each team's medical staff according to the International Olympic Committee (IOC) statement. From the study sample, 116 (36.8%) players had the RR genotype, 156 (49.5%) had the RX genotype, and 43 (13.7%) had the XX genotype. The anthropometric characteristics of the players were similar across genotypes. However, the total running distance (p = 0.046), the distance at 21.0-23.9 km/h (p = 0.042), and the number of sprints (p = 0.042) were associated with the ACTN3 genotype. In all these variables, XX players had lower match performance values than RR players. Additionally, total and match injury incidences were higher in XX players than in RR players (p = 0.026 and 0.009, respectively). The rate of muscle injuries was also higher in XX players (p = 0.016). LaLiga football players with the ACTN3 XX genotype had lower match running performance and a higher incidence of non-contact injuries over the season.

Keywords

ActininActn3 geneActn3 protein, humanAlpha-actinin-3AnthropometryArticleBody massBone densityCyclingDamageDeficiencyFast muscleFemaleFootballFootball playerGeneGene frequencyGenetic variationGeneticsGenomic dnaGenotypeGenotypingHumanHuman experimentHumansIncidenceMaleMuscleMuscle injuryMuscle massMuscle strengthMusclesPatternsPhysical performancePhysiologyProspective studiesProspective studyQtc intervalQuestionnaireRs1815739RunningSkeletal muscleSoccerSport injuryTeam sportsTraining

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Genes due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 79/191, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Genetics & Heredity. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Genetics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-10-22:

  • WoS: 3
  • Scopus: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 31 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Coso Garrigos, Juan del) .

the author responsible for correspondence tasks has been Coso Garrigos, Juan del.