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Ramiro Bargueño, JulioAutor o Coautor

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18 de noviembre de 2025
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Near-Infrared Lifetime Nanothermometry Detects Microwave-Induced Brain Heating

Publicado en: Advanced Optical Materials. 13 (36): - 2025-12-01 13(36), DOI: 10.1002/adom.202502319

Autores:

Ming, LY; Lifante, J; Pedrola, GL; Ortega, D; Zabala-Gutierrez, I; Rubio-Retama, J; Ximendes, E; Marin, R; Bargueño, JR; Jaque, D
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Afiliaciones

- Autor o Coautor
Biomed Res & Innovat Inst Cadiz, INiB Inst Invest Innovac Biomed Cadiz, Cadiz 11009, Spain - Autor o Coautor
Campus Univ Puerto Real, Fac Sci, Condensed Matter Phys Dept, Puerto Real 11510, Cadiz, Spain - Autor o Coautor
Hosp Ramon & Cajal, Inst Ramon & Cajal Invest Sanitaria IRYCIS, Nanomat Bioimaging Grp NanoBIG, Madrid 28034, Spain - Autor o Coautor
IMDEA Nanosci, Faraday 9, Madrid 28049, Spain - Autor o Coautor
McGill Univ, Montreal Neurol Inst MNI, Dept Neurol & Neurosurg, Neuroimmunol Lab, 3801 Univ Rd, Montreal, PQ H3A 2B4, Canada - Autor o Coautor
Univ Autonoma Madrid, Fac Ciencias, Dept Fis Mat, Nanomat Bioimaging Grp NanoBIG, Madrid 28049, Spain - Autor o Coautor
Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain - Autor o Coautor
Univ Autonoma Madrid, Inst Ciencia Mat Nicolas Cabrera, Madrid 28049, Spain - Autor o Coautor
Univ Ca Foscari Venezia, Dipartimento Sci Molecolari & Nanosistemi DSMN, Intelligent Opt Nanomat IONs, I-30170 Venice, Italy - Autor o Coautor
Univ Rey Juan Carlos, Dept Signal Theory & Commun Telemat & Comp, Madrid 28943, Spain - Autor o Coautor
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Resumen

In modern environments, the brain is continuously exposed to numerous external stimuli, including the microwave radiation used in telecommunication technologies. It has been suggested that the absorption of this radiation by brain tissue can induce local heating. Because brain temperature influences neural activity, metabolism, and overall brain function, microwave-induced heating raises concerns over the safety of such technologies. Proper evaluation of the risks associated with microwave-based technologies thus requires accurate quantification of heating in deep organs without disrupting their physiology. This study, demonstrates that microwave-induced brain heating can be remotely monitored in vivo via luminescence thermometry using near-infrared luminescent silver sulfide (Ag2S) nanoparticles. Their temperature-dependent luminescence lifetime is a reliable thermometric parameter for the measurement of absolute brain temperature. The in vivo results offer direct, real-time evidence of brain heating (up to 4 degrees C) under telecom exposure conditions (3 GHz). Moreover, they establish lifetime thermometry as a reliable, minimally invasive approach for investigating thermoregulation in deep tissues even under external electromagnetic stimulation.
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Palabras clave

HeatingLuminescence lifetimeLuminescence thermometryMicrowave radiationRadiationTemperatureThermal effectsTissues

Indicios de calidad

Impacto bibliométrico. Análisis de la aportación y canal de difusión

El trabajo ha sido publicado en la revista Advanced Optical Materials debido a la progresión y el buen impacto que ha alcanzado en los últimos años, según la agencia WoS (JCR), se ha convertido en una referencia en su campo. En el año de publicación del trabajo, 2025, se encontraba en la posición 15/125, consiguiendo con ello situarse como revista Q1 (Primer Cuartil), en la categoría Optics.

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Impacto y visibilidad social

Es fundamental presentar evidencias que respalden la plena alineación con los principios y directrices institucionales en torno a la Ciencia Abierta y la Conservación y Difusión del Patrimonio Intelectual. Un claro ejemplo de ello es:

  • El trabajo se ha enviado a una revista cuya política editorial permite la publicación en abierto Open Access.
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Análisis de liderazgo de los autores institucionales

Este trabajo se ha realizado con colaboración internacional, concretamente con investigadores de: Canada; Italy.

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Reconocimientos ligados al ítem

This work has been supported by Spanish Ministry of Science. The authors acknowledge support under grants PID2020- 117544RB-I00, PID2021-123318OB-I00 and CEX2020-001039-S funded by MCIN/AEI/10.13039/501100011033 and by the Comunidad Autonoma de Madrid (TEC-2024COM-360 DISCO-6G-CM) grant and co-financed by the European structural and investment fund. The authors would like to express the gratitude to the Electromagnetic Compatibility Area of the "Instituto Nacional de Tecnica Aeroespacial" (INTA) for the loan of the antenna for these experiments. The authors were grateful for the support of ZMT Zurich MedTech AG, the developer of the software used for the simulations reported in this work, Sim4Life, www.sim4life.swiss. L.M. acknowledges a scholarship from the China Scholarship Council (No. 202108350018). E.X. thanks the Community of Madrid for funding the project SI4/PJI/2024-00130 through a direct grant with Universidad Autonoma de Madrid, and also acknowledges support from grant RYC2023-044309-I, funded by MICIU/AEI (10.13039/501100011033) and the FSE. R.M. is grateful to the Spanish Ministerio de Ciencia, Innovacion y Universidades for support to research through a Ramon y Cajal Fellowship (RYC2021-032913-I) and Project 102R0103 (NAMSTEPS) funded by MICIU/AEI/10.13039/501100011033 and by FEDER, EU.
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