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Grant support

The authors acknowledge Hijos de Pablo Esparza Bodegas Navarras S.A.com pany for providing the sloe samples. This work was supported by the Complutense University of Madrid [PR26/16-16B-3] , the Community of Madrid/FEDER program [S2018/BAA-4393, AVANSECAL II-CM] and the Ministry of Science, Innovation and Universities [project PID 2020-114714RB- I00 and PID2023-149424OB-I00] .

Analysis of institutional authors

Vicente-Zurdo, DavidCorresponding Author

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October 24, 2024
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Unlocking the in vitro neuroprotection of sloe residues phenolic extracts by bioanalytical and chemometric strategies

Publicated to:Food Chemistry. 463 (Pt 2): 141208- - 2025-01-15 463(Pt 2), DOI: 10.1016/j.foodchem.2024.141208

Authors: Gomez-Mejia, Esther; Vicente-Zurdo, David; Rosales-Conrado, Noelia; Leon-Gonzalez, Maria Eugenia

Affiliations

San Pablo CEU Univ, CEU Univ, Ctr Metabol & Bioanal CEMBIO, Dept Chem & Biochem,Fac Pharm, Madrid 28660, Spain - Author
Univ Complutense Madrid, Fac Chem Sci, Dept Analyt Chem, Madrid 28040, Spain - Author

Abstract

Wild fruits, particularly the underutilized sloe (Prunus spinosa), are gaining interest as natural antioxidants, with residues from liqueur production being a source of bioactive compounds. This study proposes a sustainable approach for valorizing sloe residues, seeds and skins, by employing an innovative green extraction method. HPLC-ESI-QTOF and spectrophotometric techniques were used to explore the phenolic profile, highlighting the predominance of quercetin, 2,3-dihydroxybenzoic and ferulic acids (9.7-57 mu gg(-1)). In addition, the presence of Cu, Zn and Ca was confirmed by atomic absorption spectroscopy. Simultaneously, their neuroprotective potential against Alzheimer's disease (AD) was studied by exploring the inhibition of beta-amyloid aggregation and oxidative stress cytoprotection in SH-SY5Y cell line, standing out 1 mu gg(-1) and 10 mu gg(-1) extracts of sloe skin. Phenolic composition was correlated with bioactivities by means of multivariate analysis. These results contributed to highlight the potential of this bio-residue as a neuroprotective agent against AD in pharmaceutical and nutraceutical industries.

Keywords

A beta(42Alzheimer diseaseAlzheimer's diseaseAntioxidantsAβ 42Aβ(42)BlackthorCell line, tumorChemometric toolsChromatography, high pressure liquidCircular economyFruitHumansIdentificationIn vitro antioxidantNeuroprotective agentsOxidative stressPhenolsPlant extractsPolyphenolsSloe bio-residues

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Food Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 5/74, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Applied. Notably, the journal is positioned above the 90th percentile.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 18 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 10.85.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

Leadership analysis of institutional authors

the author responsible for correspondence tasks has been Vicente Zurdo, David.