{rfName}
Sc

Indexed in

License and use

Icono OpenAccess

Citations

68

Altmetrics

Grant support

This work was supported by the Community of Madrid/FEDER program [S2018/BAA-4393, AVANSECAL II -CM] ; the Ministry of Science, Innovation and Universities [project PID 2020-114714RB-100] ; the Spanish Ministry of Science, Innovation and Universities through a predoctoral grant [FPU18/00573] ; and the Complutense University through a pre -doctoral grant [CT17/17-CT18/17] .

Analysis of institutional authors

Vicente-Zurdo, DavidAuthor

Share

Publications
>
Article

Screening the extraction process of phenolic compounds from pressed grape seed residue: Towards an integrated and sustainable management of viticultural waste

Publicated to:Lwt-Food Science And Technology. 169 113988- - 2022-09-19 169(), DOI: 10.1016/j.lwt.2022.113988

Authors: Gomez-Mejia, Esther; Vicente-Zurdo, David; Rosales-Conrado, Noelia; Leon-Gonzalez, Maria Eugenia; Madrid, Yolanda

Affiliations

Univ Complutense Madrid, Fac Chem, Dept Anal Chem, Madrid 28040, Spain - Author

Abstract

The integrated valorisation of waste from the food chain to obtain value-added compounds with biological functionality will facilitate the transition to the era of a sustainable bioeconomy. To this end, an efficient matrix solid-phase dispersion (MSPD) extraction method was developed and optimized, using experimental factorial design and response surface methodology, for polyphenols recovery from pressed grape seeds obtained after the extraction of essential oils by cold pressing. Gallic, dihydroxybenzoic, p-coumaric and trans-ferulic acid, naringin, resveratrol, quercetin and kaempferol were quantified at 2.1-295 mu g g-1 by capillary liquid chromatography coupled to a diode array detector and a mass analyser (cLC-DAD-MS). Furthermore, total antioxidant activity, free radical scavenging and lipid peroxidation suppression, together with the inhibition of beta-amyloid (A beta 42) protein aggregation, considered one of the main pathological effects of Alzheimer's disease, were evaluated. Potent lipid peroxidation inhibition (IC50 0.238 +/- 0.003 ng g-1) was observed, along with the reduction of A beta 42 fibril width (9.4-54.8%) and aggregation. The results presented proved that the MSPD extraction method could be considered as an efficient and sustainable methodology to produce phenolic-rich extracts that may serve as an alternative antioxidant and neuroprotective ingredient for the food or pharmaceutical formulations, leading to the cascade valorisation of winery by-products.

Keywords

??42 aggregation inhibitioAntioxidant propertiesChardonnayMatrix solid-phase dispersionOiPolyphenolsPomacePressed grape seedsQuantificationSolid-phase dispersionValorisationΑβ aggregation inhibition 42

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Lwt-Food Science And Technology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 24/142, thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science & Technology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.74. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.07 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 6.42 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-13, the following number of citations:

  • WoS: 20
  • Scopus: 25
  • Google Scholar: 23
  • OpenCitations: 18

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-13:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 75 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.