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Grant support

The authors thank the funding received from the Ministry of Science, Innovation, and Universities; the State Research Agency; and the European Regional Development Fund (MCIN/AEI/10.13039/501100011033/FEDER, UE) as financing entities of the PID2022-137278OB-I00 Project (EVALKALIM-II). Moreover, the output is part of the grant PID2023-149424OB-I00, funded by MCIU/AEI/10.13039/501100011033 and ESF+ (WASTE-VIP).

Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Vicente-Zurdo, DavidAuthorMorante-Zarcero, SoniaAuthorSierra, IsabelCorresponding Author

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April 14, 2025
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Review
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Analytical Strategies for Green Extraction, Characterization, and Bioactive Evaluation of Polyphenols, Tocopherols, Carotenoids, and Fatty Acids in Agri-Food Bio-Residues

Publicated to:Molecules. 30 (6): 1326- - 2025-03-15 30(6), DOI: 10.3390/molecules30061326

Authors: Vicente-Zurdo, David; Gomez-Mejia, Esther; Morante-Zarcero, Sonia; Rosales-Conrado, Noelia; Sierra, Isabel

Affiliations

Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Analit, Ave Complutense S-N, Madrid 28040, Spain - Author
Univ Rey Juan Carlos, Escuela Super Ciencias Expt & Tecnol ESCET, Dept Tecnol Quim & Ambiental, C Tulipan S-N, Mostoles 28933, Spain - Author
Univ Rey Juan Carlos, Inst Invest Tecnol Sostenibilidad, C Tulipan S-N, Mostoles 28933, Spain - Author

Abstract

Recent advancements in analytical strategies have enabled the efficient extraction and characterization of bioactive compounds from agri-food bio-residues, emphasizing green chemistry and circular economy principles. This review highlights the valorization of several agri-food bio-residues for the extraction of high-value-added bioactive compounds, particularly polyphenols, tocopherols, carotenoids, and fatty acids, as a biorefinery approach. To this end, the adoption of environmentally friendly extraction technologies is essential to improve performance, reduce energy consumption, and minimize costs. This study therefore examines emerging methodologies such as supercritical fluid extraction, pressurized liquid extraction, pulsed electric fields, and matrix solid-phase dispersion, highlighting their advantages and limitations. Additionally, the chemical characterization of these bioactive compounds is explored through spectrophotometric and high-resolution chromatographic techniques, crucial for their accurate identification and quantification. This is complemented by an analysis of bioactivity assays evaluating antioxidant, antimicrobial, anticancer, neuroprotective, and anti-inflammatory properties, with a focus on their applications in the food, pharmaceutical, and cosmetic industries. However, the analytical control of toxic compounds, such as alkaloids, in these bio-residues is undoubtedly needed. Ultimately, this approach not only promotes sustainability but also contributes to the development of eco-friendly solutions in various industries.

Keywords

Agri-food bio-residuesAnalytical chemistryAntioxidantsBioactive compoundsBy-productsCarotenoidsCharacterizationCircular economCircular economyFatty acidsGreen chemistry technologyGreen extractionIdentificatioPhenolic-compoundsPolyphenolsQuantificationResponsible consumption and productionTocopherolsValorizationWaste

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecules due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category .

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-17:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 26.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 26 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.1.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 12 - Ensure sustainable consumption and production patterns, with a probability of 42% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Vicente Zurdo, David) and Last Author (Sierra Alonso, María Isabel).

the author responsible for correspondence tasks has been Sierra Alonso, María Isabel.