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Grant support

Research conducted for this publication was supported by Ministerio de Economia y Competitividad de Espana (BFU201678951-R, BFU2017-90578-REDT) and Comunidad de Madrid (Spain) (B2017/BMD-3684) to GMG and by Universidad Rey Juan Carlos, Madrid, Spain (Ayudas Puente, 2019) to RVB.

Analysis of institutional authors

Martin-Taboada, MAuthorVila-Bedmar, RCorresponding AuthorMedina-Gomez, GCorresponding Author

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September 27, 2022
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From Obesity to Chronic Kidney Disease: How Can Adipose Tissue Affect Renal Function?

Publicated to:Nephron. 145 (6): 609-613 - 2021-11-01 145(6), DOI: 10.1159/000515418

Authors: Martin-Taboada, Marina; Vila-Bedmar, Rocio; Medina-Gomez, Gema

Affiliations

Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Madrid, Spain - Author

Abstract

Obesity is directly associated with an increased risk of developing CKD, regardless of other comorbid conditions. Although the molecular mechanisms that link both diseases are not well established, the role of adipose tissue (AT) is becoming increasingly important in obesity-associated kidney damage. In the context of obesity, lipotoxicity and the alteration of AT secretion profile promote inflammation, oxidative stress, and fibrosis in the kidney, which ultimately leads to impaired renal function. Different studies have highlighted the importance of body weight loss in the improvement of renal function markers. In this regard, bariatric surgery, rather than low-calorie diets, has been accepted as the most effective option to lose weight. In fact, a significant reduction in proteinuria and hyperfiltration has been observed in association with surgically induced weight loss. Detection of early signs of kidney dysfunction in patients with obesity has not been accomplished yet, though. Therefore, understanding the harmful effects within the adipo-renal axis is essential to prevent the progression to the irreversible renal insufficiency. MicroRNAs have recently been described as important modulators of normal kidney function. Some of these microRNAs could be potential early markers of kidney damage, which would help with the diagnosis and the prevention of CKD.

Keywords

AdipocytokineAdipokinesAdiponectinAdipose tissueBariatric surgeryBiological markerBiomarkersChronic kidney diseaseChronic kidney failureComplicationHumanHumansKidney diseaseKidney dysfunctionKidney failure, chronicKidney functionLeptinLipotoxicityMetabolismMicrornaMicrornasNicotinamide phosphoribosyltransferaseObesityObesity managementPathophysiologyResistinReview

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nephron due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Urology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.03. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.18 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 13.5 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-05, the following number of citations:

  • WoS: 31
  • Scopus: 36
  • Europe PMC: 20

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 58.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 58 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.5.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Martín Taboada, Marina) and Last Author (Medina Gómez, Maria Gema).

the authors responsible for correspondence tasks have been Vila Bedmar, Rocío and Medina Gómez, Maria Gema.