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Analysis of institutional authors

Giron, RAuthorAbalo, RAuthorRuiz, DAuthorGoicoechea, CAuthorMartin, MiAuthor

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September 27, 2022
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Long-acting fentanyl analogues: Synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides

Publicated to: Bioorganic & Medicinal Chemistry. 10 (3): 817-827 - 2002-03-01 10(3), DOI: 10.1016/S0968-0896(01)00345-5

Authors:

Jagerovic, N; Cano, C; Elguero, J; Goya, P; Callado, LF; Meana, JJ; Girón, R; Abalo, R; Ruiz, D; Goicoechea, C; Martín, MI
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Affiliations

- Author

Abstract

The synthesis of new fentanyl analogues in which the benzene ring of the propioanilido group has been replaced by phenylpyrazole is described. Antinociceptive activity was evaluated using the writhing and hot plate tests in mice. Two compounds, 3d and 3d, showed interesting analgesic properties, being more potent than morphine and less than fentanyl but with longer duration of action. These compounds inhibited the electrically evoked muscle contraction of guinea pig ileum and mouse vas deferens but not that of rabbit vas deferens and the effects could be reversed by antagonists (naloxone and/or CTOP), thus indicating that the compounds acted as mu agonists. Finally, the binding data confirmed that the compounds had high affinity and selectivity for the mu receptor. (C) 2002 Elsevier Science Ltd. All rights reserved.
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Keywords

3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate4 [(1 oxopropyl)(1 phenylpyrazol 3 yl)amino] n piperidinepropanoic acid methyl esterAcidAgonistAmideAmidesAnalgesic agentAnalgesicsAnalgesics, opioidAnimalAnimal experimentAnimal tissueAnimalsAntagonistAntinociceptionArticleBenzene derivativeBinding affinityBinding competitionBinding, competitiveBrainCarbon nuclear magnetic resonanceCavia porcellusChemistryDextro phenylalanylcysteinyltyrosyl dextro tryptophylornithylthreonylpenicillaminylthreoninamide 2,7 disulfideDrug bindingDrug derivativeDrug effectDrug potentiationDrug selectivityDrug synthesisEvaluationEvoked muscle responseFentanylFentanyl derivativeGuinea pigGuinea pigsHot plate testHumanHuman cellHumansIleumKappa-opioid receptorMaleMiceMorphineMouseMu opiate receptorMu opiate receptor agonistMu-opiateMuscle contractionN (1 phenylpyrazol 3 yl) n (1 benzyl 4 piperidyl)propanamideN (1 phenylpyrazol 3 yl) n [1 (2 phenethyl) 4 piperidyl)]propanamideN (1 phenylpyrazol 5 yl) n (1 benzyl 4 piperidyl)propanamideN (1 phenylpyrazol 5 yl) n [1 (2 phenethyl) 4 piperidyl)propanamideN methyl n [7 (1 pyrrolidinyl) 1 oxaspiro[4.5]dec 8 yl]benzeneacetamideN [1 (4 fluorophenyl)pyrazol 3 yl] n (1 benzyl 4 piperidyl)propanamideN [1 (4 fluorophenyl)pyrazol 3 yl] n [1 (2 phenethyl) 4 piperidyl)]propanamideNaloxoneNarcotic analgesic agentNonhumanNuclear magnetic resonance spectroscopyOryctolagus cuniculusPainPotentPropionamide derivativeProton nuclear magnetic resonancePyrazole derivativePyrazolesRabbitRabbitsReceptors, opioid, muSelectivityStructure activity relationStructure-activity relationshipSus scrofaSynthesisTimeTime factorsUnclassified drugVas deferensWrithing test

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Bioorganic & Medicinal Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2002, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmaceutical Science.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • WoS: 28
  • Scopus: 33
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 48.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 48 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Martín Claudio, María Isabel).

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