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This work was supported by Ministerio de Ciencia e Innovacion (SAF2009-12422-C02-01 and SAF2012-40075-C02-01) and Comunidad de Madrid (S-SAL/0261/2006 and S2010/BMD-2308).

Analysis of institutional authors

Giron, RAuthorAbalo, RCorresponding Author

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September 27, 2022
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Fluoroscopic Characterization of Colonic Dysmotility Associated to Opioid and Cannabinoid Agonists in Conscious Rats

Publicated to:Journal Of Neurogastroenterology And Motility. 25 (2): 300-+ - 2019-04-01 25(2), DOI: 10.5056/jnm18202

Authors: Diaz-Ruano, Susana; Lopez-Perez, Ana E; Giron, Rocio; Perez-Garcia, Irene; Martin-Fontelles, Maria I; Abalo, Raquel

Affiliations

CSIC, CIAL, Unidad Asociada IDial, Inst Invest Ciencias Alimentac, Madrid, Spain - Author
CSIC, IQM, Unidad Asociada IDial, Madrid, Spain - Author
Grp Multidisciplinar Invest & Tratamiento Dolor I, Grp Excelencia Invest URJC Banco Santander, Madrid, Spain - Author
Hosp Gen Univ Gregorio Maranon, Serv Anestesiol, Unidad Dolor, Madrid, Spain - Author
Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Avda Atenas S-N, Madrid 28922, Spain - Author
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Abstract

Background/Aims Gastrointestinal adverse effects have a major impact on health and quality of life in analgesics users. Non-invasive methods to study gastrointestinal motility are of high interest. Fluoroscopy has been previously used to study gastrointestinal motility in small experimental animals, but they were generally anesthetized and anesthesia itself may alter motility. In this study, our aim is to determine, in conscious rats, the effect of increasing doses of 2 opioid (morphine and loperamide) and 1 cannabinoid (WIN 55,212-2) agonists on colonic motility using fluoroscopic recordings and spatio-temporal maps. Methods Male Wistar rats received barium sulfate intragastrically, 20-22 hours before fluoroscopy, so that stained fecal pellets could be seen at the time of recording. Animals received an intraperitoneal administration of morphine, loperamide, or WIN 55,212-2 (at 0.1, 1, 5, or 10 mg/kg) or their corresponding vehicles (saline, Cremophor, and Tocrisolve, respectively), 30 minutes before fluoroscopy. Rats were conscious and placed within movement-restrainers for the length of fluoroscopic recordings (120 seconds). Spatio-temporal maps were built, and different parameters were analyzed from the fluoroscopic recordings in a blinded fashion to evaluate colonic propulsion of endogenous fecal pellets. Results The analgesic drugs inhibited propulsion of endogenous fecal pellets in a dose-dependent manner. Conclusions Fluoroscopy allows studying colonic propulsion of endogenous fecal pellets in conscious rats. Our method may be applied to the non-invasive study of the effect of different drug treatments and pathologies.

Keywords

AnalgesicsAnalgesics, opioidsBlood-brain-barrierCannabinoidsColonic motilityDigestaFluoroscopyGastrointestinal motilityGuinea-pigLarge-intestineMotor functionsOpioidsPainQuantitative-analysisRatsTransitWin-55,212-2

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Neurogastroenterology And Motility due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 82/204, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Clinical Neurology. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Gastroenterology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-16:

  • WoS: 5
  • Scopus: 4
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 20.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network Facebook: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Abalo Delgado, Raquel).

the author responsible for correspondence tasks has been Abalo Delgado, Raquel.