{rfName}
Ge

Indexed in

License and use

Citations

55

Altmetrics

Grant support

The project was supported by a grant from the Novo Nordisk Foundation 0067235 (Denmark) and by a grant associated to the Fondo Europeo De Desarrollo Regional-Recursos REACT-UE del Programa Operativo de Madrid 2014-2020, en la linea de actuacion de proyectos de I + D + i en materia de respuesta a COVID-19 (LONG-COVID-EXP-CM). Both sponsors had no role in the design, collection, management, analysis, or interpretation of the data, draft, review, or approval of the manuscript or its content. The authors were responsible for the decision to submit the manuscript for publication, and the sponsor did not participate in this decision.

Analysis of institutional authors

Fernandez-De-Las-Penas, CesarCorresponding AuthorDiaz-Gil, GemaAuthorGomez-Esquer, FranciscoAuthorGil-Crujera, AntonioAuthorGomez-Sanchez, Stella MAuthorAmbite-Quesada, SilviaAuthorPalomar-Gallego, Maria AAuthor
Share
Publications
>
Article

Genetic Association between ACE2 (rs2285666 and rs2074192) and TMPRSS2 (rs12329760 and rs2070788) Polymorphisms with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors

Publicated to:Genes. 13 (11): 1935- - 2022-11-01 13(11), DOI: 10.3390/genes13111935

Authors: Fernandez-de-las-Penas, Cesar; Arendt-Nielsen, Lars; Diaz-Gil, Gema; Gomez-Esquer, Francisco; Gil-Crujera, Antonio; Gomez-Sanchez, Stella M; Ambite-Quesada, Silvia; Palomar-Gallego, Maria A; Pellicer-Valero, Oscar J; Giordano, Rocco

Affiliations

Aalborg Univ Hosp, Dept Med Gastroenterol, Mech Sense, DK-9000 Aalborg, Denmark - Author
Aalborg Univ, SMI, Dept Hlth Sci & Technol, Fac Med,Ctr Neuroplast & Pain CNAP, DK-9220 Aalborg, Denmark - Author
Univ Rey Juan Carlos URJC, Dept Basic Hlth Sci, Res Grp GAMDES, Alcorcon 28922, Spain - Author
Univ Rey Juan Carlos, Dept Phys Therapy Occupat Therapy Rehabil & Phys, Alcorcon 28922, Spain - Author
Univ Valencia, ETSE Engn Sch, Dept Elect Engn, Intelligent Data Anal Lab, Valencia 46100, Spain - Author
See more

Abstract

The aim of the study was to identify the association between four selected COVID-19 polymorphisms of ACE2 and TMPRSS2 receptors genes with the presence of long-COVID symptomatology in COVID-19 survivors. These genes were selected as they associate with the entry of the SARS-CoV-2 virus into the cells, so polymorphisms could be important for the prognoses of long-COVID symptoms. Two hundred and ninety-three (n = 293, 49.5% female, mean age: 55.6 +/- 12.9 years) individuals who had been previously hospitalized due to COVID-19 were included. Three potential genotypes of the following single nucleotide polymorphisms (SNPs) were obtained from non-stimulated saliva samples of participants: ACE2 (rs2285666), ACE2 (rs2074192), TMPRSS2 (rs12329760), TMPRSS2 (rs2070788). Participants were asked to self-report the presence of any post-COVID defined as a symptom that started no later than one month after SARS-CoV-2 acute infection and whether the symptom persisted at the time of the study. At the time of the study (mean: 17.8, SD: 5.2 months after hospital discharge), 87.7% patients reported at least one symptom. Fatigue (62.8%), pain (39.9%) or memory loss (32.1%) were the most prevalent post-COVID symptoms. Overall, no differences in long-COVID symptoms were dependent on ACE2 rs2285666, ACE2 rs2074192, TMPRSS2 rs12329760, or TMPRSS2 rs2070788 genotypes. The four SNPs assessed, albeit previously associated with COVID-19 severity, do not predispose for developing long-COVID symptoms in people who were previously hospitalized due to COVID-19 during the first wave of the pandemic.

Keywords
Ace2Ace2 geneAce2 protein, humanAdultAgedAgeusiaAmnesiaAngiotensin converting enzyme 2Angiotensin-converting enzyme 2AnosmiaArticleAsthmaCardiovascular diseaseChronic obstructive lung diseaseClouding of consciousnessConcentration lossControlled studyCoronavirus disease 2019Covid-19Cross-sectional studyDiabetes mellitusDna extractionDyspneaEye diseaseFatigueFemaleGastrointestinal diseaseGeneGenetic polymorphismGenomic dnaGenotypeGenotypingHair lossHospital dischargeHospitalizationHumanHumansHypertensionHypogeusiaHyposmiaIntensive care unitLong covidLong-covidMajor clinical studyMaleMiddle agedNasopharyngeal swabNonhumanOral swabPainPandemicPeptidyl-dipeptidase aPolymorphism, single nucleotidePost-acute covid-19 syndromePost-covidPrevalenceRashReal time reverse transcription polymerase chain reactionSars-cov-2Self reportSerine endopeptidasesSevere acute respiratory syndrome coronavirus 2SeveritySingle nucleotide polymorphismSurvivorSurvivorsTmprss2Tmprss2 geneTmprss2 protein, humanTransmembrane protease serine 2

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Genes due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 66/171, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Genetics & Heredity. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Genetics.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.04. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.26 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 9.28 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-19, the following number of citations:

  • WoS: 17
  • Scopus: 24
  • Europe PMC: 14
  • OpenCitations: 17
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 60.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 60 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.25.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Denmark.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Fernández de las Peñas, César) .

the author responsible for correspondence tasks has been Fernández de las Peñas, César.