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This research was supported by the Spanish Ministry of Health, Instituto de Salud Carlos III, RETICS RD06/0011 (REM-TAP Network), CIBER-SAM, CDTEAM, Program CENIT of the Spanish Ministry of Industry, and the Juan de la Cierva program of the Spanish Ministry of Education and Science.

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García Vázquez, VerónicaAuthor

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January 4, 2023
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Regional Gray Matter Volume Deficits in Adolescents With First-Episode Psychosis

Publicated to:Journal Of The American Academy Of Child And Adolescent Psychiatry. 47 (11): 1311-1320 - 2008-11-01 47(11), DOI: 10.1097/CHI.0b013e318184ff48

Authors: Janssen, Joost; Reig, Santiago; Parellada, Mara; Moreno, Dolores; Graell, Montserrat; Fraguas, David; Zabala, Arantzazu; Garcia Vazquez, Veronica; Desco, Manuel; Arango, Celso;

Affiliations

Hosp Univ Gregorio Maranon, Adolescent Unit, Madrid 28007, Spain - Author
Hosp Univ Gregorio Maranon, Lab Imagen Med, Dept Med & Cirugia Expt, Madrid 28007, Spain - Author
Hosp Univ Nino Jesus, Adolescent Unit, Madrid, Spain - Author

Abstract

Objective: The current study combined baseline voxel-based morphometry and 1-year clinical follow-up assessments to examine whether and where regional gray matter (GM) volumes differed between a control group and diagnostic subgroups of early-onset first-episode psychosis (FEP). Method: Magnetic resonance imaging brain scans were obtained from 70 patients with early-onset FEP, and 51 non-FEP controls. Early-onset FEP was defined as age younger than 18 years and a duration of positive symptoms of less than 6 months. The age range of the sample was 7 to 18 years. After a 1-year follow-up, patients were stratified into three subgroups: schizophrenia (n = 25), bipolar I disorder (n = 20), and other psychoses (n = 25). Regional GM volumes of each patient subgroup were compared with those of the control group. Results: A follow-up diagnosis of schizophrenia was associated with GM volume deficits in the left medial and left middle frontal gyrus: bipolar I disorder was related to a GM volume deficit in the left medial frontal gyrus; and not having a follow-up diagnosis of schizophrenia or bipolar disorder was associated with smaller bilateral GM volumes in the insula and right middle occipital gyrus. Conclusions: Left medial frontal GM volume deficits were common in the groups with schizophrenia and bipolar I disorder, which may point to shared underlying pathological findings. J. Am. Acad. Child Adolesc. Psychiatry. 2008;47(11):1311 1320.

Keywords

AdolescenceBipolar disorderBrain abnormalitiesChildhood-onset schizophreniaChildrenCingulateGreyMagnetic resonance imagingModelPrefrontal cortexPsychosisRandom-fieldSchizophreniaVoxel-based morphometry

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of The American Academy Of Child And Adolescent Psychiatry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2008, it was in position 1/86, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pediatrics.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 8.16, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 68

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 65.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 69 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.