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This research was supported by the Spanish Ministry of Health, Instituto de Salud Carlos III, RETICS RD06/0011 (REM-TAP Network), CIBER-SAM, CDTEAM, Program CENIT of the Spanish Ministry of Industry, and the Juan de la Cierva program of the Spanish Ministry of Education and Science.

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Regional Gray Matter Volume Deficits in Adolescents With First-Episode Psychosis

Publicado en:Journal Of The American Academy Of Child And Adolescent Psychiatry. 47 (11): 1311-1320 - 2008-11-01 47(11), DOI: 10.1097/CHI.0b013e318184ff48

Autores: Janssen, Joost; Reig, Santiago; Parellada, Mara; Moreno, Dolores; Graell, Montserrat; Fraguas, David; Zabala, Arantzazu; Garcia Vazquez, Veronica; Desco, Manuel; Arango, Celso;

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Objective: The current study combined baseline voxel-based morphometry and 1-year clinical follow-up assessments to examine whether and where regional gray matter (GM) volumes differed between a control group and diagnostic subgroups of early-onset first-episode psychosis (FEP). Method: Magnetic resonance imaging brain scans were obtained from 70 patients with early-onset FEP, and 51 non-FEP controls. Early-onset FEP was defined as age younger than 18 years and a duration of positive symptoms of less than 6 months. The age range of the sample was 7 to 18 years. After a 1-year follow-up, patients were stratified into three subgroups: schizophrenia (n = 25), bipolar I disorder (n = 20), and other psychoses (n = 25). Regional GM volumes of each patient subgroup were compared with those of the control group. Results: A follow-up diagnosis of schizophrenia was associated with GM volume deficits in the left medial and left middle frontal gyrus: bipolar I disorder was related to a GM volume deficit in the left medial frontal gyrus; and not having a follow-up diagnosis of schizophrenia or bipolar disorder was associated with smaller bilateral GM volumes in the insula and right middle occipital gyrus. Conclusions: Left medial frontal GM volume deficits were common in the groups with schizophrenia and bipolar I disorder, which may point to shared underlying pathological findings. J. Am. Acad. Child Adolesc. Psychiatry. 2008;47(11):1311 1320.

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