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The financial support of the Spanish government (Grant Nos. CTQ2017-88642-R and PID2021-125216OB-I00) and Rey Juan Carlos University (Grant No. 2022/00004/010) is gratefully acknowledged.

Analysis of institutional authors

Navas, FranciscoAuthorVictoria Fuentes, MaAuthorGiraldez, IsabelAuthorCeballos, LauraCorresponding AuthorMorales, VictoriaAuthorSanz, RaúlAuthorGarcia-Munoz, Rafael ACorresponding Author

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January 9, 2023
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L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria

Publicated to:Journal Of Nanobiotechnology. 20 (1): 502- - 2022-12-01 20(1), DOI: 10.1186/s12951-022-01714-0

Authors: Lopez-Ruiz, Marta; Navas, Francisco; Fernandez-Garcia, Paloma; Martinez-Erro, Samuel; Victoria Fuentes, Ma; Giraldez, Isabel; Ceballos, Laura; Ferrer-Luque, Carmen Ma; Ruiz-Linares, Matilde; Morales, Victoria; Sanz, Raul; Garcia-Munoz, Rafael A

Affiliations

Rey Juan Carlos Univ, Dept Chem & Environm Technol, C Tulipan S-N Mostoles, Madrid 28933, Spain - Author
Rey Juan Carlos Univ, Fac Hlth Sci, IDIBO Res Grp, Madrid, Spain - Author
Univ Granada, Sch Dent, Dept Stomatol, Campus Cartuja,Colegio Maximo S-N, Granada 18071, Spain - Author

Abstract

Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out from the dental adhesive, effectively contributing to the reduction of the bacterial strains Streptococcus mutans and Lactobacillus casei. Furthermore, the mechanical and bonding properties of the dental adhesive did not change significantly after the incorporation of L-arginine-containing MSNs. These results are yielding glimmers of promise for the cost-effective prevention of secondary caries.

Keywords

2 hydroxyethyl methacrylateAcidityAdhesive agentAdhesive resinsAdhesivesAlkalinityAntibacterialAntibacterial activityArginineArticleBacteriaBacteriumBacterium cultureBenzoic acid derivativeBiocompatibilityBiofilmBisphenol a bis(2 hydroxypropyl) ether dimethacrylateCaries lesionsCariogenic bacteriumControlled drug deliveryControlled studyCost effectivenessDental adhesiveDental adhesivesDental cariesDental cementsDental materialDrug delivery systemDrug delivery systemsDrug designDrug determinationDrug formulationDrug releaseDrug structureDrug synthesisDrug targetingDrug-delivery systemsEmbedded systemsEthyl 4 (dimethylamino) benzoateFormulationHumanHumansIn vitro studyL-arginineLactobacillus caseiLongevityMechanicsMesoporous silica nanoparticleMesoporous silica nanoparticlesMicrotensile bond strengthModulusN oleoylarginineN,n'-diacetyl-1,6-diaminohexaneNanoparticleNanoparticlesNonhumanOral bacteriaOral diseasePhysical chemistryResin compositesResin-compositesRestorationsSecondary cariesSilica nanoparticlesSilicon dioxideStreptococcus gordoniiStreptococcus mutansSystemTargeted drug deliveryTensile strengthTooth cementUnclassified drug

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Nanobiotechnology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 12/158, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biotechnology & Applied Microbiology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.6. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.52 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 12.1 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-14, the following number of citations:

  • WoS: 17
  • Scopus: 19
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-14:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 30.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 30 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Granada.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author () and Last Author (García Muñoz, Rafael Ángel).

the authors responsible for correspondence tasks have been Ceballos García, Laura and García Muñoz, Rafael Ángel.