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RTI2018-094322-B-I00 and TED2021-132175B-I00 funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe", by the "European Union" (for RTI) or by the "European Union NextGenerationEU/PRTR" (for TED).

Analysis of institutional authors

Mendez-Arriaga, Jose M MAuthorGomez-Ruiz, SantiagoCorresponding Author

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February 27, 2023
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Review
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Gold Nanozymes: Smart Hybrids with Outstanding Applications

Publicated to:Catalysts. 13 (1): 13- - 2023-01-01 13(1), DOI: 10.3390/catal13010013

Authors: Jimenez-Falcao, Sandra; Mendez-Arriaga, Jose M M; Garcia-Almodovar, Victoria; Garcia-Valdivia, Antonio A; Gomez-Ruiz, Santiago

Affiliations

Univ Complutense Madrid, Fac Ciencias Quim, Madrid 28040, Spain - Author
Univ Granada, Fac Ciencias, Dept Quim Inorgan, Granada 18071, Spain - Author
Univ Rey Juan Carlos, Dept Biol & Geol Fis & Quim Inorgan, COMET NANO Grp, Madrid 28933, Spain - Author

Abstract

Nanozymes are nanostructured artificial enzymes that have attracted great attention among researchers because of their ability to mimic relevant biological reactions carried out by their natural counterparts, but with the capability to overcome natural enzymes' drawbacks such as low thermostability or narrow substrate scope. The promising enzyme-like properties of these systems make nanozymes excellent candidates for innovative solutions in different scientific fields such as analytical chemistry, catalysis or medicine. Thus, nanozymes with different type of activities are of special interest owing to their versatility since they can reproduce several biological reactions according to the substrates and the environmental conditions. In this context, gold-based nanozymes are a representative example of multifunctional structures that can perform a great number of enzyme-like activities. In addition, the combination of gold-based materials with structures of organic and inorganic chemical nature yields even more powerful hybrid nanozymes, which enhance their activity by providing improved features. This review will carry out a deep insight into gold-based nanozymes, revisiting not only the different type of biological enzymatic reactions that can be achieved with these kinds of systems, but also structural features of some of the most relevant hybrid gold-based nanozymes described in the literature. This literature review will also provide a representative picture of the potential of these structures to solve future technological challenges.

Keywords

Artificial enzymesCarbonCatalytic-activityColorimetric detectionEnzyme activityGlucoseGold nanoparticlesHybrid materialsHydrogen-peroxideMimickingNanoparticlesNanozymePeroxidase-like activitySwitchable peroxidase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Catalysts due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 74/178, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Chemistry, Physical. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Physical and Theoretical Chemistry.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.8, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 8
  • Scopus: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author () and Last Author (Gómez Ruiz, Santiago).

    the authors responsible for correspondence tasks have been and Gómez Ruiz, Santiago.