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Analysis of institutional authors

Recio, JavierAuthor

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September 26, 2023
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A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis

Publicated to: European Journal Of Medicinal Chemistry. 202 112600- - 2020-09-15 202(), DOI: 10.1016/j.ejmech.2020.112600

Authors: Bazan, Hernan A; Bhattacharjee, Surjyadipta; Burgos, Carolina; Recio, Javier; Abet, Valentina; Pahng, Amanda R; Jun, Bokkyoo; Heap, Jessica; Ledet, Alexander J; Gordon, William C; Edwards, Scott; Paul, Dennis; Alvarez-Builla, Julio; Bazan, Nicolas G

Affiliations

Louisiana State Univ Hlth New Orleans, Neurosci Ctr Excellence, Sch Med, New Orleans, LA 70112 USA - Author
Louisiana State Univ Hlth New Orleans, Sch Med, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA - Author
Louisiana State Univ Hlth New Orleans, Sch Med, Dept Physiol, New Orleans, LA 70112 USA - Author
Ochsner Clin & Alton Ochsner Med Fdn, Sect Vasc Endovasc Surg, Dept Surg, New Orleans, LA 70118 USA - Author
Southeast Louisiana Vet Hlth Care Syst, New Orleans, LA 70119 USA - Author
Univ Alcala, Dept Organ Chem, Madrid 28805, Spain - Author
Univ Alcala, IQAR, Madrid 28805, Spain - Author
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Abstract

Although acetaminophen (ApAP) is one of the most commonly used medicines worldwide, hepatotoxicity is a risk with overdose or in patients with compromised liver function. ApAP overdose is the most common cause of acute fulminant hepatic failure. Oxidation of ApAP to N-acetyl-p-benzoquinone imine (NAPQI) is the mechanism for hepatotoxicity. 1 is a non-hepatotoxic, metabolically unstable lipophilic ApAP analog that is not antipyretic. The newly synthesized 3 is a non-hepatotoxic ApAP analog that is stable, lipophilic, and retains analgesia and antipyresis. Intraperitoneal or po administration of the new chemical entities (NCEs), 3b and 3r, in concentrations equal to a toxic dose of ApAP did not result in the formation of NAPQI. Unlike livers from NCE-treated mice, the livers from ApAP-treated mice demonstrated large amounts of nitrotyrosine, a marker of mitochondrial free radical formation, and loss of hepatic tight junction integrity. Given the widespread use of ApAP, hepatotoxicity risk with overuse, and the ongoing opioid epidemic, these NCEs represent a novel, non-narcotic therapeutic pipeline. (C) 2020 The Authors. Published by Elsevier Masson SAS.

Keywords

AcetamideAcetamidesAcetaminophenAcetic acidAnalgesiaAnalgesicsAnimalsAntipyresisAntipyreticsApap-induced liver injury (aili)Chemical and drug induced liver injuryDose-response relationship, drugDrug-drug interaction (ddi)EdemaHepatotoxicityHyperthermiaLiverMaleMiceMolecular structureNovel acetaminophen/paracetamol analogsPainRatsStructure-activity relationshipToxicity

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal European Journal Of Medicinal Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 5/62, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-06:

  • WoS: 7
  • Scopus: 6
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 38.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 38 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 636.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).
  • The number of mentions in news outlets: 87 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

Awards linked to the item

We gratefully acknowledge FEDER funds and Comunidad de Madrid (CAM, project B2017/BMD-3688 MULTI-TARGET&VIEW-CM FEDER FUNDS), Ministerio de Economia, Industria y Competitividad (project CTQ2017-85203-P), Instituto de Salud Carlos III (FEDER funds, ISCIII RETIC REDINREN RD16/0009/0015 FEDER FUNDS) and Universidad de Alcal~a (CCG2017/EXP-021 and CCG2018/EXP-051) for financial support. J. R. also thanks the Universidad de Alcala for a predoctoral grant. We thank Mr. Jeremy E. Mix for their assistance with animal care and analgesia assays.