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García Gómez De Las Heras SAuthor

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November 8, 2023
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Prognostic role of the number of resected and negative lymph nodes in Spanish patients with gastric cancer

Publicated to:Annals Of Diagnostic Pathology. 67 152209- - 2023-12-01 67(), DOI: 10.1016/j.anndiagpath.2023.152209

Authors: del Arco, CD; Medina, LO; Muñoz, LE; Roldán, EM; de las Heras, SGG; Aceñero, MJF

Affiliations

Department of Basic Medical Sciences, School of Medicine, Rey Juan Carlos University, Móstoles, Madrid, Spain - Author
Department of Basic Medical Sciences, School of Medicine, Rey Juan Carlos University, Móstoles, Madrid, Spain, Department of Pathology, Rey Juan Carlos Hospital, Móstoles, Madrid, Spain - Author
Department of Pathology, Hospital Clínico San Carlos - Author
Hosp Clin San Carlos IdISSC, Hlth Res Inst, Madrid, Spain - Author
Hosp Clin San Carlos, Biobank, Madrid, Spain - Author
Hosp Clin San Carlos, Dept Pathol, Madrid, Spain - Author
Hosp Clin San Carlos, Dept Surg Pathol, C Prof Martin Lagos S-N, Madrid 28040, Spain - Author
Pathology Teaching Unit, Department of Legal Medicine, Psychiatry and Pathology, School of Medicine, Complutense University of Madrid, Madrid, Spain, Department of Pathology, Hospital Clínico San Carlos - Author
Rey Juan Carlos Hosp, Dept Pathol, Madrid, Spain - Author
Rey Juan Carlos Univ, Sch Med, Dept Basic Med Sci, Madrid, Spain - Author
Univ Complutense Madrid, Sch Med, Dept Legal Med Psychiat & Pathol, Pathol Teaching Unit, Madrid, Spain - Author
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Abstract

Introduction: Lymph node (LN) involvement is one of the most critical prognostic factors in resected gastric cancer (GC). Some analyses, mainly conducted in Asian populations, have found that patients with a higher number of total lymph nodes (NTLN) and/or negative lymph nodes (NNLN) have a better prognosis, although other authors have failed to confirm these results. Materials and methods: Retrospective study including all patients with GC resected in a tertiary hospital in Spain between 2001 and 2019 (n = 315). Clinicopathological features were collected and patients were categorized according to the NTLN and the NNLN. Statistical analyses were performed. Results: Mean NNLN was 17. The NNLN was significantly related to multiple clinicopathological variables, including recurrence and tumor-related death. The classification based on the NNLN (N1: ?16, N2: 8–15, N3: ?7) effectively stratified the entire cohort into three distinct prognostic groups and maintained its prognostic value within both the pN0 and pN+ patient subsets. Furthermore, it was an independent prognostic indicator for both overall and disease-free survival. Conversely, the mean NTLN was 21.9. Patients with ?16 LN retrieved exhibited distinct clinicopathological features compared to those with >16 LN, but no significant differences were observed in terms of recurrence or disease-associated death. The application of alternative cut-off points for NTLN (10, 20, 25, 30, and 40) showed no prognostic significance. Conclusions: In Spanish patients with resected GC the NNLN hold prognostic significance, while the NTLN does not appear to be prognostically significant. Incorporating the NNLN into GC staging may enhance the accuracy of the TNM system. © 2023 Elsevier Inc.

Keywords

AdultAgedArticleCancer adjuvant therapyCancer free survivalCancer mortalityCancer patientCancer prognosisCancer recurrenceCancer sizeCancer stagingCancer surgeryCardiaClinical featureCohort analysisControlled studyFemaleGastrectomyGastric cancerHistopathologyHumanHuman tissueLinitis plasticaLymph node countLymph node dissectionLymph node metastasisLymph nodesLymph vessel metastasisMajor clinical studyMaleNegativeOverall survivalPerineural invasionPredictive valuePrognosisRetrospective studySpainStomach cancerStomach corpusStomach fundusTertiary care centerTotalTreatment outcomeTumor volumeWestern

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Annals Of Diagnostic Pathology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Pathology and Forensic Medicine. Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Pathology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 3.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.85.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).