{rfName}
Pr

Indexed in

License and use

Citations

Altmetrics

Analysis of institutional authors

Noguero Meseguer M.r.Author

Share

Publications
>
Article

Prognostic Value of Hormone Receptors, Human Epidermal Growth Factor Receptor, Cyclins D1 and D2, B-cell lymphoma 2 and Cyclooxygenase-2 in Young Patients with Breast Cancer

Publicated to:Progresos En Obstetricia Y Ginecologia. 56 (5): 242-247 - 2013-05-01 56(5), DOI: 10.1016/j.pog.2012.07.010

Authors: Noguero Meseguer MR; Yago Lisbona L; Segovia Blázquez B; Muñoz Díez MM; Martín Gutiérrez S; Carpintero Franco R; Sancho Pérez B; Gallego Alvarez M; Sanz Ferrández MC; Mendizábal Urízar JL

Affiliations

Abstract

Objetive: To investigate the value of hormone receptor (HR) status, HER-2, cyclins D1 and D2, bcl-2 and cyclooxygenase-2 (COX-2) in predicting the outcome of very young breast cancer patients (below 35 years). Subjects and method: In this study HR, HER-2, cyclins D1 and D2, bcl-2 and COX-2 were determined for a second time by immunohistochemistry and tissue arrays in a cohort of 71 patients aged less than 35 years with known outcome. The prognostic influence of these factors was evaluated by the chi-square test and Kaplan Meier method. Results: Expression of HR was detected in 67% of the patients, HER-2 in 48.6%, cyclins D1 and D2 in 59.1% and 59.7%, respectively, bcl-2 in 62.5% and COX-2 in 63.4% of breast tumors. HR and COX-2 overexpression were significantly correlated with a major risk of local relapse (OR: 4.6, P=.03 for HR and OR: 3.7, P=.02 for COX-2). Conclusions: Increased expression of HR and COX-2 may play a role in the progression of primary breast carcinoma in very young patients. Overexpression of cyclins D1 and D2 and bcl-2 had no prognostic value. © 2010 SEGO.

Keywords

Age less than 35B-cell lymphoma 2Breast cancerCyclinsCyclooxygenase-2Hormonal receptorsHuman epidermal growth factor receptor 2

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Progresos En Obstetricia Y Ginecologia, Q4 Agency Scopus (SJR), its regional focus and specialization in Obstetrics and Gynecology, give it significant recognition in a specific niche of scientific knowledge at an international level.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-06:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Noguero Meseguer, María Rosario) .