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Prognostic Value of Hormone Receptors, Human Epidermal Growth Factor Receptor, Cyclins D1 and D2, B-cell lymphoma 2 and Cyclooxygenase-2 in Young Patients with Breast Cancer

Publicado en:Progresos En Obstetricia Y Ginecologia. 56 (5): 242-247 - 2013-05-01 56(5), DOI: 10.1016/j.pog.2012.07.010

Autores: Noguero Meseguer MR; Yago Lisbona L; Segovia Blázquez B; Muñoz Díez MM; Martín Gutiérrez S; Carpintero Franco R; Sancho Pérez B; Gallego Alvarez M; Sanz Ferrández MC; Mendizábal Urízar JL

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Objetive: To investigate the value of hormone receptor (HR) status, HER-2, cyclins D1 and D2, bcl-2 and cyclooxygenase-2 (COX-2) in predicting the outcome of very young breast cancer patients (below 35 years). Subjects and method: In this study HR, HER-2, cyclins D1 and D2, bcl-2 and COX-2 were determined for a second time by immunohistochemistry and tissue arrays in a cohort of 71 patients aged less than 35 years with known outcome. The prognostic influence of these factors was evaluated by the chi-square test and Kaplan Meier method. Results: Expression of HR was detected in 67% of the patients, HER-2 in 48.6%, cyclins D1 and D2 in 59.1% and 59.7%, respectively, bcl-2 in 62.5% and COX-2 in 63.4% of breast tumors. HR and COX-2 overexpression were significantly correlated with a major risk of local relapse (OR: 4.6, P=.03 for HR and OR: 3.7, P=.02 for COX-2). Conclusions: Increased expression of HR and COX-2 may play a role in the progression of primary breast carcinoma in very young patients. Overexpression of cyclins D1 and D2 and bcl-2 had no prognostic value. © 2010 SEGO.

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